Custom Peptides
Cayman Chemical SchIsndrol B 10mg
A lignan with hepatoprotective activity; increases the expression of the PXR target genes Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells; protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not Pxr-null, mice; decreases mortality in a mouse model of cholestasis at 100 mg/kg twice per day
Cayman Chemical somernzn 10mg
A coumarin with antioxidant and anti-inflammatory activities; inhibits superoxide anion generation in, and elastase release from, cytochalasin B- and fMLP-stimulated isolated human neutrophils (IC50s = 3.89 and 4.33 µM, respectively); inhibits LPS-induced NO release in RAW 264.7 macrophages at 30 µM; improves survival in a mouse model of LPS-induced septic shock and decreases disease severity in a mouse model of DSS-induced colitis at 30 mg/kg
Cayman Chemical RosIglItazon 10mg
A PPARγ agonist; activates PPARγ1 and PPARγ2 in reporter assays (EC50s = 30 and 100 nM, respectively); selectively activates chimeras containing the LBDs of PPARγ over PPARα and PPARδ in a cell-based reporter assay at 10 mM; an inhibitor of ACSL4 (IC50 = 0.5 µM), inhibits RSL3-induced ferroptosis in Pfa1 cells and Pparg KO cells, and increases survival in a Gpx4 KO mouse model of ferroptosis at 0.0125 mg/ml in the drinking water; decreases HbA1c and fasting blood glucose levels in a rat model of type 2 diabetes induced by STZ and a high-carbohydrate and high-fat diet at 4 mg/kg
Cayman Chemical 4ChLRomethcathInonhydroc 10mg
An analog of methcathinone that has a chlorine atom inserted at the 4 position of the phenyl ring; intended for forensic and research applications
Cayman Chemical 2 3Pentylon Isomerhydroch 10mg
A structural isomer of pentylone, having the methylenedioxy group attached at carbons 2 and 3 of the terminal phenyl group; intended for forensic and research applications
Cayman Chemical N-BenzylpalmItamIde 10mg
A long-chain fatty acid amide isolated from the maca plant that moderately inhibits FAAH activity (44% inhibition at 500 µM); many members of this family demonstrate selective antiproliferative activity against diverse cancer cell lines
Cayman Chemical DapIglutIdesodIum salt 10mg
A dual GLP-1R and GLP-2R agonist; induces cAMP accumulation in HEK293 cells expressing human GLP-1R or GLP-2R (EC50s = 190 and 210 pM, respectively); reduces peak blood glucose levels in an oral glucose tolerance test and increases intestinal wet weight in mice at 6 nmol/kg; decreases gastric emptying and increases intestinal weight and length in rats (ED50s = 7.6, 20.7, and 10.7 nmol/kg, respectively); promotes body weight recovery, decreases stool water content, and increases intestinal villus height and intestinal length in a mouse model of short bowel and intestinal insufficiency induced by 40% ileocecal resection
Cayman Chemical Prenylamn 10mg
A calcium channel inhibitor; inhibits PMCA in isolated and purified pig cardiac sarcolemma; binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a Kd value of 0.5 µM and inhibits CaM-activated cAMP PDE activity at 10-50 µM, an effect that is negatively associated with the concentration of calmodulin; shortens action potentials and decreases the inward calcium current in single guinea pig ventricular myocytes in the absence and presence of propranolol and phentolamine at 30 μM; decreases epinephrine, serotonin, and dopamine levels in rat brain at 50 mg/kg; decreases epinephrine levels in rat heart; protects anesthetized rats from coronary artery occlusion-induced arrhythmia at 0.5 mg/kg but increases mortality due to atrioventricular block leading to asystole at 5 mg/kg
Cayman Chemical DeterenolhydrochlorIde 10mg
A β-adrenergic receptor agonist; increases tension in isolated right and left guinea pig atria and trachea (IC50s = 0.411, 1.44, and 8.37 µM, respectively), which endogenously express β-ARs, but has no effect on isolated rabbit aortic strips, which express α-ARs; induces lipolysis in human adipocytes
Cayman Chemical 5CarytetramthylrhodamIn 10mg
A fluorescent dye; has been used for the covalent labeling of oligonucleotides for DNA analysis, fluorescence polarization assays, and protein FRET experiments; ex/em = 546/580 nm
Cayman Chemical PentagastrIn 10mg
A synthetic polypeptide and CCK2 receptor agonist; binds selectively to CCK2 in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1,100 nM, respectively); increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s = 23 and 3.9 nM, respectively); increases histidine decarboxylase activity in mucous and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 = 2.9 nM); induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 = 30 pM); increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s = 1.29 and 57.3 nmol/kg2 per hour, respectively)
Cayman Chemical LRRKtIDtrIfluoROCTAte sa 10mg
A peptide substrate for LRRK2; has been used to identify inhibitors of LRRK2
Cayman Chemical OrforglIpron 10mg
A nonpeptide GLP-1R agonist; induces cAMP accumulation in HEK293 cells expressing human GLP-1R (EC50 = 3.05 nM); selective for GLP-1R over the GCGR, GIP receptor, and GLP-2R at 100 nM; ) prevents increases in blood glucose levels in glucose-injected mice expressing human GLP-1R but not in glucose-injected Glp1r-/- mice at 0.1, 1, or 10 mg/kg; decreases blood glucose and serum insulin levels in glucose-injected cynomolgus monkeys at 5.4 mg/kg; reduces mean food intake in cynomolgus monkeys at 0.05 or 0.1 mg/kg per day
Cayman Chemical 13C64NItrophenylhydrazIn 10mg
An internal standard for the quantification of 4-nitrophenylhydrazine by GC- or LC-MS; a byproduct in the synthesis of 13C6-3-nitrophenylhydrazine
Cayman Chemical MItoquInonmesylate 10mg
An oxidized form of mitoquinol; reduced to mitoquinol in isolated bovine heart mitochondrial membranes using succinate for respiration at 50 µM; increases the rate of hydrogen peroxide formation in isolated BAECs at 0.01-10 µM; induces cell death in isolated mouse pancreatic acinar cells at 1 µM; in combination with mitoquinol, reduces MDA levels in isolated rat liver mitochondria and decreases caspase activity in Jurkat cells